Author

Lukas E. Dow

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Open access Aug 2026

Role of orphan G protein-coupled receptor GPR52 in breast cancer cell multicellular organization and collective invasion.

Loss of the orphan GPCR GPR52 in human breast cell lines leads to increased cell clustering, hybrid/partial EMT, and increased tumour burden in zebrafish, further expanding the understanding of mechanisms driving cancer progression and opening the door to novel therapeutic approaches.

Sarah Z. Hanif, Caleb Kutz, C. C. Au et al. · British Journal of Cancer · 0 citations

Open access Jul 2026

Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis.

To define mutation-specific lineage reversion and tumor initiation, Ptf1a-tdTomato mice and multiple KRAS mutants are implemented across several genetic, pharmacologic, and inflammatory perturbations in vivo to deciphering mutation-specific oncogenic trajectories and directing the implementation of KRAS-directed therap...

A. Grimont, David Falvo, W. Sisso et al. · Developmental Cell · 1 citation