Open access
Sep 2026
FFAR2 activation induces IL-22-dependent intestinal immune responses to suppress CNS autoimmunity.
It is shown that selective oral activation of free fatty acid receptor 2 (FFAR2) with the synthetic agonist Cpd1 effectively ameliorates established experimental autoimmune encephalomyelitis (EAE), demonstrating therapeutic efficacy after the onset of the autoimmune response.
B. Jevtić, Milica Lazarević, Goran Stegnjaić et al.
· EMBO Molecular Medicine · 0 citations