Innate immune responses must be tightly controlled to maintain immuno-homeostasis. However, the regulatory mechanisms underlying the activation and early stages of the innate immune response remain poorly defined. Here, we found the soluble C-type lectin Clec18a is up-regulated in multiple inflammatory diseases, includ...
Zheng-Yu Jiang, Lu-Long Bo, Na Li et al.· bioRxiv· 0 citations
Ischemia-reperfusion injury (IRI) contributes to the pathogenesis of major diseases, including acute kidney injury, stroke, and myocardial infarction. Multiple forms of cell death, including apoptosis, necroptosis, pyroptosis, autophagy, and ferroptosis, are key contributors to IRI. The interplay among these cell-death...
Chuan-Gang Yao, Qi Wu, Zhi Wang et al.· Biomarker Research· 0 citations
Background: To determine the median effective dose (ED 50 ) of tegileridine for immediate postoperative analgesia following laparoscopic colorectal cancer surgery (LCRS), and to evaluate its safety profile. Methods: A modified Dixon’s up-and-down sequential method was employed, starting with an initial tegileridine dos...
Minna Guo, Tong Wang, Shuchi Lin et al.· Drug Design, Development and...· 0 citations
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