Association of a Pre-miR-1453 Polymorphism with Growth Traits and Serum Biochemical Parameters in an F2 Chicken Population
Simple Summary Background: MicroRNAs are small molecules that help control how genes work in animals, and they play important roles in growth and development. This study investigated a specific genetic change (single-nucleotide polymorphism, SNP) in a microRNA called miR-1453 and its relationship with growth and health traits in chickens. Method: A total of 860 chickens from a special breeding population were examined; this population was created by crossing slow-growing Gushi chickens with fast-growing Anka broilers. Result: The results showed that this genetic change was linked to differences in hatch weight, as well as body weight measured at 2 and 4 weeks post-hatching, alongside altered levels of specific serum proteins and enzymes. The genetic change also affected the shape and stability of the miR-1453 molecule. Target gene prediction and pathway analysis suggested that miR-1453 may influence chicken growth through pathways involved in nerve development, cell structure, and energy use. Conclusions: These results indicate that this genetic marker could be useful for selecting chickens with better growth performance in breeding programs.