Modular Orthogonal Dual-Channel Gold Nanosensor Platform for Ratiometric Imaging of Tumor-Associated Macrophage M1/M2 Polarization
The phenotypic balance between M1 and M2 tumor-associated macrophages (MΦs) governs tumor immune homeostasis and immunotherapeutic outcomes. However, in situ visualization of this polarization equilibrium remains challenging. Conventional histological and cytological approaches only afford static ex vivo phenotyping,...