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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

Lyn H. Jones

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Open access Oct 2026

Intrinsic Reactivity of Sulfonyl Imidazole and Triazole Electrophiles for Covalent Probe Design.

Sulfonyl exchange electrophiles are increasingly used in covalent probe and drug discovery, yet their intrinsic reactivity and plasma stability remain poorly defined, limiting rational warhead selection. Here we establish a systematic LC-MS framework to quantify the reactivity of sulfonyl imidazole and triazole electro...

Paramita Pal, Hannah M. Unsworth, Lyn H. Jones · 0 citations
Open access Oct 2026

Conformational switch of NPC1 epitomizes a lumen-to-membrane alternating access model for nonpolar substrates.

Niemann-Pick disease type C (NPC) arises from failure of the NPC1 and/or NPC2 proteins to mobilize lysosomal cholesterol, yet the mechanism by which the complex drives sterol translocation lacks a thorough understanding. Here, we capture an NPC1-NPC2 complex conformation at lysosomal pH using a bis-sterol ligand (JM046...

Xue-Lan Wu, Sepehr Dehghani-Ghahnaviyeh, A. Rasouli et al. · 0 citations

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