Open access
Jul 2026
The roles of neuroticism, genetic susceptibility, and amygdala structure in chronic musculoskeletal pain onset and recovery.
High neuroticism scores, neuroticism PRS, and CMP PRS were significantly associated with increased risk of CMP onset and reduced likelihood of recovery across cohorts, highlighting a potential neurobiological mechanism linking psychological vulnerability to chronic pain.
M. Cannistra, Yu Liu, V. Sacca et al.
· Communications Medicine · 0 citations