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Author

Mohamed A. Ali

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Oct 2026

Hesperidin-mediated selenium nanoparticles protect against diabetic cisplatin-induced testicular injury via modulation of Nrf2/Keap1, TLR4/NF-κB/MAPK, and PERK/CHOP Signaling.

BACKGROUND Type 2 diabetes mellitus (T2DM) and cisplatin-induced toxicity are major contributors to male reproductive dysfunction. The present study investigated the protective impacts of hesperidin (HSP), sodium selenite, and hesperidin-mediated selenium nanoparticles (HSP-SeNPs) against testicular damage induced by t...

I. Jafri, E. Fayad, Khalaf N. Alsiaam et al. · 0 citations
Oct 2026

Quercetin-mediated selenium nanoparticles protect against hyperthyroidism-induced hepatic injury: Involvement of Nrf2/NF-κB signaling, mitochondrial apoptosis, and iron/heme imbalance.

PURPOSE Hyperthyroidism-associated liver injury represents an important extra-thyroidal complication of thyroid hormone excess, driven by increased metabolic demand and interconnected oxidative, inflammatory, and mitochondrial disturbances. However, the coordinated involvement of Nrf2/NF-κB signaling, apoptosis, and ir...

M. A. Ali, Khaled M. Alam-Eldein, Gannat Elsayed et al. · 0 citations

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