Integrated In silico and In Vitro Evaluation of Piperine Derivatives as Potential Efflux Pump Inhibitors in Methicillin-Resistant Staphylococcus aureus
The increasing prevalence of antibiotic resistance mediated by efflux pump activity represents a major challenge in the treatment of infections caused by methicillin-resistant Staphylococcus aureus (MRSA). Efflux pumps such as NorA and MepA reduce intracellular antibiotic accumulation and contribute significantly to...