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Author

M. A. Moustafa

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Sep 2026

Thieno[2,3-d]pyrimidine scaffold optimization for synergistic c-Met/STAT3 blockade: Synthesis, structure-activity relationships, in vitro potency, and apoptotic pathways in colorectal cancer.

Compounds 17d and 17e were found to be the most potent and exhibited significant anticancer activity across a wide range of cancer cell lines within the NCI-60 panel and are promising leads for further development of dual c-Met/STAT3 inhibitors for treating colorectal cancer.

S. I. El-Desouky, Hesham Haffez, Mohamed S. Nafie et al. · 0 citations

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