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Author

M. Abernathy

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Open access Sep 2026

Structural basis of diverse antibody recognition of conserved coronavirus spike S2 epitopes that contribute to protective immunity

These findings expand the genetic, structural and functional landscape of human antibody responses to conserved coronavirus S2 epitopes and demonstrate that CH-directed antibodies can contribute to protective immunity through Fc-dependent mechanisms not predicted by in vitro neutralization or conventional in vitro Fc e...

Adonis A. Rubio, Virginia Crivelli, Václav Hönig et al. · 0 citations
Jul 2026

Structural characterization of antibodies binding the conserved central helix and membrane-proximal lower stalk of coronavirus spike glycoprotein 2248624

Monoclonal antibodies from COVID-19 convalescent donors are identified that target two conserved epitopes in the S2 domain of the coronavirus Spike glycoprotein: the central helix and the lower stalk, advancing knowledge of two conserved and structurally vulnerable sites within the coronavirus S2 subunit.

Adonis A. Rubio, M. Abernathy, Davide F. Robbiani et al. · 0 citations
Open access Sep 2026

Dissociation kinetics and avidity gate SARS-CoV-2 neutralization by HR2 stem helix antibodies

It is shown that plasma IgG reactivity to this region remains rare, even after repeated antigen exposure, and kinetic and avidity constraints governing neutralization at the HR2 stem helix and position hr2.016 as a resilient therapeutic candidate.

Virginia Crivelli, Concetta Guerra, M. Abernathy et al. · 0 citations
Open access Aug 2026

Structural and mutational analyses define distinct molecular routes to broad SARS-CoV-2 receptor-binding domain recognition

Two human-derived monoclonal antibodies are characterized that recognize conserved epitopes on the SARS-CoV-2 RBD and retain activity across antigenically distinct variants, and conserved, mutationally constrained epitopes may serve as targets for vaccines designed to elicit antibody responses resilient to ongoing SARS...

M. Abernathy, William B. Foreman, Jasmyn A. Lopez et al. · 0 citations

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