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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

M. Agbaga

h-index 26 View on Semantic Scholar

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Open access Aug 2026

PEDF/PEDF-R Signaling Regulates Retinal Phospholipid Homeostasis and Photoreceptor Survival

Pigment epithelium-derived factor (PEDF) promotes photoreceptor survival through its receptor PEDF-R, a phospholipase involved in retinal lipid metabolism. To define the in vivo function of the PEDF/PEDF-R axis, we generated mice lacking Serpinf1 (PEDF) and Pnpla2 (PEDF-R). Combined loss of Serpinf1 and Pnpla2 resulted...

Alexandra Bernardo-Colón, Susan E. Crawford, M. Agbaga et al. · 0 citations
Open access Jul 2026

Chronic Hypoxic Signalling Reprograms Metabolism and Alters Redox and Lipid Homeostasis in Rod Photoreceptors

Outdoor segment lipidomics revealed selective remodelling of phosphatidylcholine and phosphatidylethanolamine species toward more oxidation-resistant and elongated acyl chains, supported by early gene upregulation of essential enzymes involved in fatty acid elongation, desaturation and oxidation.

Larissa P. Govers, Daniel T. Hass, M. Agbaga et al. · 0 citations
Open access Jul 2026

TMEM135 deficiency remodels hepatic lipid homeostasis and protein malonylation through a DHA-sensitive lipogenic program buffered by peroxisomal metabolism

These findings identify TMEM135 as a central regulator of hepatic lipid metabolism and uncover a coordinated mechanism linking lipid availability, lipogenesis, and post-translational metabolic regulation.

Ryo Hagimori, Michael Landowski, Siyu Song et al. · 0 citations

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