Targeting the NLRP3 inflammasome pathway associated with neuroinflammation mediated Alzheimer's disease: pre-clinical and clinical status of emerging therapeutics.
This review breaks down the pathways triggered by immune cells activation (neurotoxic microglial phenotype) and majorly focusing over the NLRP3 inflammasome neuroinflammation pathway, exploring the promising therapeutic potential of specific bioactive phytochemicals, repurposed and novel synthetic drugs/agents to shut-down this molecular switch.