Author

M. Arnold

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Open access Oct 2026

DNA methylation profiling reveals novel rhabdomyosarcoma subsets with distinct histologic, genetic and clinical properties

Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma, and is commonly divided into fusion-positive (FP) (predominantly PAX3::FOXO1 or PAX7::FOXO1) and fusion-negative (FN) subtypes. Based on our earlier finding of different DNA methylation patterns in the FP and FN subtypes, we hypothesized that ther...

W. Sun, J. Lopez-Nava, J. Shern et al. · medRxiv · 0 citations

Open access Oct 2026

A Subset of FOXO1‐Fusion Negative Rhabdomyosarcoma With Round Cell (Alveolar) and “Burkitt‐Like” Morphology Is Associated With High Amplification of MYCL: A Report From the Children's Oncology Group

Alveolar rhabdomyosarcoma (ARMS) is a distinct histologic subtype of rhabdomyosarcoma, associated with the presence of a PAX3 or PAX7::FOXO1 gene fusion in approximately 80% of cases. Adverse outcomes for patients with ARMS are associated with the presence of a FOXO1 gene fusion; however, additional genetic markers are...

Sonja D. Chen, Wei Xue, Cora A. Ricker et al. · Genes, Chromosomes and Cance... · 0 citations

Sep 2026

Abstract C018: DNA methylation profiling reveals novel rhabdomyosarcoma subsets with distinct histologic, genetic and clinical properties

DNA methylation profiling provides a robust approach for subcategorizing the RMS family of soft tissue tumors into more homogeneous subsets, and confirms the presence of two major subsets (FN1 and FN2) in FN RMS as well as PAX3::FOXO1- and PAX7::FOXO1-enriched subsets in FP RMS.

Wen-Yue Sun, J. Lopez-Nava, J. Shern et al. · Cancer Research · 0 citations