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Dual-Target Inhibition of Puumala Virus Entry Glycoproteins Gn and Gc by Moringa oleifera -Derived Phytochemicals: An Integrated Computational Study
Puumala virus (PUUV), a member of the Orthohantavirus genus, causes nephropathia epidemica, an intermediate type of hemorrhagic fever with renal dysfunction, yet no approved antiviral therapy is currently available. Viral entry is initiated by the coordinated actions of the attachment glycoprotein Gn and fusion gly...
Taxonomic and functional concordance between full-length ONT 16S and ONT shotgun metagenomics in the canine gut microbiome
Background Full-length Oxford Nanopore Technologies (ONT) 16S rRNA sequencing provides a scalable view of microbial community composition and can support phylogeny-based functional prediction, but it is not equivalent to shotgun metagenomics. We asked which biological conclusions are preserved when the same canine feca...