Theta oscillations, epileptogenesis, and focal seizures in rodent models of mesial temporal lobe epilepsy.
Theta oscillations (4-12 Hz) are a prominent network rhythm within hippocampal and parahippocampal structures. Driven by cholinergic and γ-aminobutyric acidergic inputs originating from the medial septum, physiological theta gates network excitability to control spatial navigation, memory encoding, and sensorimotor int...