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Circulatory proteome is a promising tool to capture distinct tissue-specific responses that correlate with disease activity and tissue injury in patients with IIM.
Cell-type enrichment analysis indicating a broad cellular origin of the circulating proteome, with contributions from nervous system cells, vascular cells, immune cells, and muscle cells, highlights the potential of plasma proteomics for clinically meaningful patient stratification in ALS.
The importance of a pan-disease approach to identify robust and disease-informative protein panels for improved classification of SARDs is demonstrated and disease-specific proteins that differentiate systemic autoimmune rheumatic diseases are identified.
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