M. Bajaj

One-Carbon Metabolic Reprogramming Stratifies Prognosis and Defines Distinct Biological States in IDH1-Mutant Gliomas

Background IDH1 mutations in diffuse gliomas undergo epigenetic transformation and metabolic stress, through accumulation of 2-hydroxyglutarate. While these tumours generally exhibit a less aggressive phenotype, significant prognostic heterogeneity persists. The extent to which the One Carbon Metabolism (OCM) network i...