Author

M. Bakun

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Open access Aug 2026

Integrated Multi-Omics and Interactome Analysis of CDK8 Inhibition Reveals Erythroid Differentiation Programs and Therapeutic Synergy with BET Blockade in AML

Findings identify CDK8 as a transcriptional node of LSC-associated programs and provide a mechanistic rationale for combined CDK8-BET inhibition in molecularly defined AML subsets, which will require validation in functional LSC assays and primary specimens.

M. Statkiewicz, I. Rumieńczyk, U. Pakulska et al. · Cells · 0 citations

Open access Aug 2026

TTC33 forms a complex with WDR61 and PHF5A to recruit factors relevant to genomic integrity

Using a combination of biochemical assays, structural modeling and molecular dynamics, it is shown that TTC33 directly recruits WDR61 and PHF5A to assemble into a trimeric core complex (TANC), which then forms distinct interactions with either UNG1/2 or SF3B–CCDC97.

R. Tomecki, Małgorzata Drabko, Małgorzata Siek et al. · Nature Communications · 0 citations