Open access
Aug 2026
Extensive binding of poorly characterized human transcription factors to genomic dark matter
It is found that induction of TPRX1, a known regulator of zygotic preimplantation, leads to chromatin opening at many of its binding sites in the dark matter genome, suggesting that the genome encodes many putative transcription factors.
Rozita Razavi, Ali Fathi, Isaac Yellan et al.
· Nature Communications · 3 citations