Synthesis, cytotoxicity, and antimicrobial activity of triphenylphosphonium (TPP) conjugates of 1,2,3-triazolyl analogues of pyrimidine nucleosides bearing N-acetyl-β-D-glucosamine residue.
A series of triphenylphosphonium (TPP) conjugates of 1,2,3-triazolyl analogues of pyrimidine nucleosides was synthesized. In these compounds a TPP cation was attached via a decamethylene linker to the atom N-3 of the nucleic base (uracil, thymine) or its analog (6-methyluracil), and the N-acetyl-β-D-glucosamine residue...