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Author

M. Berretta

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Review Open access Oct 2026

Morphology-Guided Diagnosis of Triple-Negative Breast Carcinoma: From Histopathological Evaluation to Molecular Testing

Background: Triple-negative breast carcinoma (TNBC) comprises several histological entities with different molecular alterations and clinical behaviour. Recognising these entities is important for accurate classification and for choosing appropriate immunohistochemical and molecular tests. Methods: We conducted a narra...

V. Zuccalà, Ida Rizzuto, L. Pepe et al. · 0 citations
Review Open access Sep 2026

Mechanisms of resistance to PARP inhibitors in advanced epithelial ovarian cancer: biological determinants and therapeutic implications

PARP inhibitors have become an integral component of treatment strategies for advanced epithelial ovarian cancer, particularly in BRCA1/2-mutated and homologous recombination-deficient (HRD) tumors. Despite clinically meaningful improvements in progression-free survival, a substantial proportion of patients develop pri...

D. Incognito, G. Ciappina, G. Ettore et al. · 0 citations
Review Open access Aug 2026

PIK3CA in Cancer: Structure, Biology, Alterations, and Actionability

This review provides a comprehensive, updated, and comparative overview of PIK3CA biology, its molecular alterations across human cancers, their prognostic and therapeutic relevance, and the current development of treatments targeting the pathway activated by PIK3CA.

A. Ottaiano, C. Picone, M. Santorsola et al. · 0 citations

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