Author

M. Bilotta

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Sep 2026

Rational design of hybrid hydrazide-hydrazone/thiourea derivatives as potential VEGFR-2 targeting anticancer agents: synthesis, biological evaluation, and mechanistic insights into anticancer activity.

Overall, this study identifies MIH-36 as a promising lead compound with a multifaceted anticancer activity profile, associated with reduced proliferation, migration, and survival of breast cancer cells, potentially through modulation of VEGFR-2-associated pathways.

Guzide Satir-Basaran, Ahmed Amleh, Antonio Curcio et al. · Bioorganic chemistry (Print) · 0 citations

Open access Aug 2026

An Integrated Consensus Machine Learning and Structure-Based Workflow for the Discovery of Novel Tankyrase 1 Inhibitors

The proposed workflow efficiently reduced a large chemical space to a focused set of TNKS1 inhibitor candidates while substantially reducing the experimental screening burden, highlighting the value of integrating consensus ML, SBVS, and experimental validation to accelerate early-stage hit discovery for TNKS1 and othe...

M. Bilotta, Adriana Gargano, R. Rocca et al. · Pharmaceuticals · 0 citations