Transcatheter aortic valve replacement (TAVR) induces a thromboinflammatory response characterized by hypercoagulability and dynamic platelet alterations. The integrated mechanisms underlying these changes remain incompletely defined.
To comprehensively characterize periprocedural hemostatic and inflammato...
D. Hesselbarth, A. Hoelzle, S. Teegelbekkers et al.· European Heart Journal· 0 citations
Y-encoded genes are unlikely to drive cancer through direct transcriptional regulation of autosomal genes, directing attention to non-transcriptional effects of LOY.
Alex Waterhölter, R. Scholz, Andreas Tsouris et al.· bioRxiv· 0 citations
Common variable immunodeficiency (CVID) is frequently complicated by autoimmune and inflammatory manifestations associated with profound immune dysregulation (CVIDc), including expansion of T-bethighCD21low B cells (CD21low B cells). Elevated serum IL-10 levels have repeatedly been reported in CVIDc, yet their relation...
Victoria Cousin, A. Graumann, V. Geiger et al.· Journal of Clinical Immunolo...· 0 citations
The lack of experimental systems that faithfully model the genetic and phenotypic progression from Barrett’s esophagus (BE) to gastroesophageal adenocarcinoma (GEAC) has limited mechanistic discovery and preclinical testing. Here, we report a refined L2-IL-1B based mouse model engineered to capture two hallmark alterat...
Akanksha Anand, Linus R. Schoemig, Lioba Klaas et al.· Scientific Reports· 0 citations
Pegtarazimod reduced aGVHD in mice by suppressing pro inflammatory neutrophil effector functions and preserving enterocyte integrity and the clinical trial data support tolerability of pegtarazimod in aGVHD patients and further studies are needed to determine efficacy.
Verena Holzmüller, Jana Gawron, Ann-Cathrin Burk et al.· Journal of Clinical Investig...· 0 citations
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