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Loss of RanBP9 cooperates with p53 deficiency to promote sarcomagenesis
Introduction Ubiquitination is a major regulatory process that is often dysregulated in carcinogenesis. The C-terminal to LisH (CTLH) complex is a multi-subunit E3 ubiquitin ligase that has been shown to exert tumor-promoting and tumor-suppressing functions. Its core scaffolding subunit, RanBP9, has been implicated in...
Lipoprotein(a): a unique lipoprotein at the crossroads of atherosclerosis and thrombosis.
Accumulating evidence indicates that considering the prothrombotic activities of Lp(a) will impact clinical management of Lp(a) and the deployment of Lp(a)-lowering therapies.