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Author

M. Boutros

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Open access Sep 2026

TCF4 and CtBP1 Repress LEF1 to Maintain a TCF4-centric Transcriptional Program in Colon Cancer

The canonical WNT signaling pathway guides cell growth throughout the human lifespan. In adults, WNT plays an essential role in tissue homeostasis by maintaining tissue stem cells. In the intestine, the WNT transcription factor, TCF4, is necessary for stem cell maintenance. Aberrant activation of WNT signaling is gener...

Markus A. Brown, Sanam Yaghoubi, Juliane Kamlah et al. · 0 citations
Oct 2026

Visualizing Protein Trafficking in Whole Tissue Context Using Super-Resolution Nanoscopy in Drosophila.

The fruit fly Drosophila melanogaster is widely used to study conserved developmental and cellular signaling pathways in vivo. Many signaling pathways, including Wnt signaling, depend on tightly regulated secretion, endocytosis, and intracellular trafficking events. However, visualizing the dynamics of membrane-associa...

Michaela Holzem, Bojana Pavlović, Claudia Strein et al. · 0 citations

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