Type I IFN coordinates resistance and tolerance against Zika virus disease by inducing NK cell recruitment and limiting neutrophil-driven neuropathology in the brain
Zika virus (ZIKV) neurological disease arises from both direct viral cytopathic effects in the central nervous system (CNS) and host-driven neuroinflammation, with disease outcomes determined by the balance between antiviral resistance and disease tolerance. Type I interferons (IFN-I) are well-established antiviral med...