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Author

M. Brīvība

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Open access Nov 2026

Identifying novel genomic alterations in relapsed childhood B-ALL: a report from the Children's Oncology Group.

Relapsed B-acute lymphoblastic leukemia (B-ALL) generally occurs due to the emergence of subclones resistant to therapy, leading to poor outcome. Here, we describe novel genomic alterations responsible for therapeutic resistance at a subtype level in a clinical trial (AALL1331) which randomized patients to blinatumomab...

Yuan Feng, Han-Xia Li, H. Mulder et al. · 0 citations
Open access Oct 2026

Polygenic risk for type 2 diabetes modulates gut microbiome associations across metabolic health traits

In this study, we integrated phenotype data, genotyping, and gut metagenomic data to investigate how genetic predisposition to T2D interacts with the gut microbiome, as well as attenuating lifestyle factors, across metabolic health traits in a cohort of 821 individuals of European ancestry. We evaluated increased B...

Lauma Jagare, I. Elbere, M. Rozenberga et al. · 0 citations

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