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Author

M. Cetiner

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Open access Aug 2026

Precision Medicine in patients with rare forms of genetic obesity: Necessity for coordinated and structured care.

Advances in research enable precision medicine for rare metabolic diseases. The approval of therapies as melanocortin-4 receptor (MC4R) agonists for the treatment of hyperphagia and obesity in monogenic disorders (POMC, PCSK1, and LEPR deficiencies) and Bardet-Biedl syndrome (BBS), affecting fewer than 1 in 20,000 (BBS...

Karine Clément, I. Farooqi, Peter Kühnen et al. · 0 citations
Open access Aug 2026

Melanocortin-4 Receptor Regulation of Endocrine Axes and Clinical Effects of Setmelanotide.

Setmelanotide exerts pleiotropic effects beyond weight reduction, modulating multiple endocrine axes in BBS, and the observed changes highlight MC4R signaling pathway as a key integrator of metabolic and endocrine function and suggest partially weight-independent therapeutic effects.

T. Hühne, E. Steidel, J. Holland et al. · 0 citations

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