The Activity of Antimicrobial Peptides (AMPs) Identified Via an Integrated in Silico and Pilot in Vitro Screening Approach Towards ESKAPE Pathogens.
A stability-centric computational discovery pipeline to identify and characterize novel antimicrobial peptides with potent and selective bactericidal activity against ESKAPE pathogens and to validate the lead candidates through experimental in vitro assays provided a generally applicable strategy for accelerating the discovery of peptide-based therapeutics.