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Author

M. Cruellas

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Review Open access Oct 2026

CDH1 germline carriers and diffuse gastric Cancer: Are we ready for personalized surveillance and prevention?

Hereditary diffuse gastric cancer (HDGC) caused by germline pathogenic or likely pathogenic variants in CDH1 remains a difficult hereditary cancer syndrome to manage. Prophylactic total gastrectomy has long been considered the most definitive preventive strategy, but recent penetrance estimates, expert endoscopic surve...

M. Cruellas, J. Castillo-Iturra, Tian V. Tian et al. · 0 citations
Open access Jul 2026

Impact of BRCA2 pathogenic variants on outcomes to first-line CDK4/6 inhibitors plus endocrine therapy in HR-positive/HER2-negative metastatic breast cancer

BRCA2 PVs were independently associated with poorer outcomes to first-line CDK4/6i plus ET in HR-positive/HER2-negative MBC compared with controls, especially relevant among patients with endocrine-sensitive disease.

M. Cruellas, A. Rodriguez-Hernandez, L. Carità et al. · 0 citations

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