Bioactivity-Guided Optimization of 3-Deoxyanthocyanidin Extraction and Seasonal Mapping of Four Morphotypes of Fridericia chica (Bonpl.) L.G. Lohmann
Ultrasound-assisted extraction (UAE) was combined with a design of experiments (DoE) to optimize the recovery of 3-deoxyanthocyanidins (3D-anths) from Fridericia chica leaves using in vitro antileishmanial activity against Leishmania amazonensis promastigotes as a bioactivity-guided response. A 3 × 3 factorial design e...