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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

M. Dattani

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Open access Aug 2026

P256 - ECE_2728 - Impact of setmelanotide on metabolic index scores in Phase 3 trial participants with acquired hypothalamic obesity

The findings highlight the broad metabolic benefits and strong clinically meaningful efficacy of setmelanotide in this population, supporting its potential as a therapeutic option for patients with aHO and suggest reductions in visceral fat burden, hepatic steatosis, and overall cardiometabolic risk.

H. V. van Santen, S. Phillips, J. Hamilton et al. · 0 citations
Open access Aug 2026

P255 - ECE_1844 - Efficacy and safety of setmelanotide in acquired hypothalamic obesity: Results from a double-blind, multicentre, placebo-controlled, randomised phase 3 trial

In the largest randomised, placebo-controlled trial in aHO to date, setmelanotide demonstrated significant effects over placebo in the primary and key secondary efficacy endpoints at 52 weeks, with no new safety signals.

S. Phillips, H. V. van Santen, J. Hamilton et al. · 0 citations
Clinical trial Open access Jul 2026

Setmelanotide for the Treatment of Acquired Hypothalamic Obesity.

Setmelanotide led to significantly greater reductions in BMI and hunger than placebo at 52 weeks among participants 4 to 66 years of age with acquired hypothalamic obesity.

J. Miller, H. V. van Santen, Susan A. Phillips et al. · 6 citations · ⚡2
Open access Aug 2026

CCDC149: a novel gene associated with hypopituitarism and neurodevelopmental impairment.

This study is the first to report CCDC149 variants in association with Congenital Hypopituitarism, supporting the possibility of impaired ciliary function as an underlying mechanism in this complex disorder.

L. Gregory, Shoshana Rath, Hanna Mandel et al. · 0 citations

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