Open access
Sep 2026
Characterization of FLT3-ITD-mutated leukemic stem cells: functional and clinical insights
Despite treatment advances, relapsed/refractory FLT3 -ITD-mutated acute myeloid leukemia ( FLT3 -ITD mut AML) remains an unmet medical need. We previously identified a CD34/CD123/CD25/CD99+ leukemic progenitor cell (LPC) population that persists after induction treatment and drives disease recurrence in FLT3...
S. Travaglini, T. Ottone, S. Antonelli et al.
· Cell Death Discovery · 0 citations