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M. Dostalík

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Open access Aug 2026

Plaque-associated oligodendrocyte proteostatic failure underlies myelin loss in Alzheimer’s disease

Alzheimer’s disease (AD) features amyloid-β plaques and tau pathology, yet the mechanism underlying early and clinically significant myelin loss remains unresolved. Here, we report human iPSC-derived forebrain organoids with doxycycline-inducible expression of SOX10, OLIG2, and NKX6-2 (SON), which generate robust, matu...

Jong Shin, Nandita Joshi, Brendan F. Miller et al. · bioRxiv · 0 citations