MurNAc-Based Electrophilic Inhibitors of O-Acetylpeptidoglycan Esterase (Ape): Design, Synthesis, and Kinetic Evaluation.
Peptidoglycan (PG) is the key structural component of the bacterial cell wall, responsible for cellular shape and structural integrity. Postsynthetic modifications to PG enable bacteria to evade innate immunity and regulate endogenous autolysins. Among these, C-6 O-acetylation protects PG from lysozyme degradation, whi...