Author

M. Elgeti

2 papers indexed here

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Open access Sep 2026

Reconstructing hidden GPCR conformations and ligand binding modes through integrative DEER modeling.

Binding of biased ligands to a G protein-coupled receptor (GPCR) stabilizes specific receptor conformations, leading to distinct physiological responses. Recently, intra-transducer bias has emerged as an additional mechanism that fine-tunes receptor function by stabilizing specific architectures of the receptor-transdu...

J. Belyaeva, M. Elgeti · Structure · 0 citations

Open access Jul 2026

Conformational Basis of Functionally Selective Allosteric Modulation of the Angiotensin II type 1 Receptor by Small Molecules

The DNA- encoded library screening-guided isolation and pharmacological characterization of the first small molecule AT1R allosteric ligands are reported, uncovering new mechanisms for precisely controlling the dynamic behavior of the AT1R with implications for drug development targeting this pathophysiologically impor...

Samuel Liu, Peng Xiao, M. Elgeti et al. · bioRxiv · 0 citations