M. Elhai

When inflammation is not the driver: Pauci-immune synovitis and the stromal basis of refractory arthritis.

Approximately 5% to 20% of patients with rheumatoid arthritis (RA) fail to respond to sequential biologic and targeted synthetic disease-modifying antirheumatic drugs, representing a major unmet clinical need. Increasing evidence indicates that a substantial proportion of these patients exhibit a pauci-immune (fibroid)...