Open access
Sep 2026
PRDM9-mediated meiotic hotspot specification is constrained in humans despite extensive sequence diversity
PRDM9 specifies meiotic recombination hotspots through a rapidly evolving C2H2 zinc-finger (ZNF) coding minisatellite that determines DNA-binding specificity. Although this minisatellite harbors extraordinary allelic diversity in humans, the functional consequences of most naturally occurring variants remain unknown. H...
Rachel L. Cosby, Marja Brolinson King, Alexandra M. Poch et al.
· bioRxiv · 0 citations