Author

M. F. Hussein

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Oct 2026

Benzodiazepine-based N,S-heterocyclic hybrids as multi-target therapeutic candidates for cancer and inflammation: enzymatic evaluation, cellular mechanistic studies, in vivo anti-inflammatory assessment, and computational investigations.

A series of eleven novel benzodiazepine-based N, S-heterocyclic hybrids incorporating thienothiazine and thienopyrimidine scaffolds was designed, synthesized, and characterized by spectroscopic and analytical techniques. Compounds 4 and 6 showed favorable selectivity against HCT-116 and MDA-MB-231 cells relative to nor...

Hagar S. El-Hema, M. A. Abed, M. A. Hawata et al. · Bioorganic chemistry (Print) · 0 citations

Open access Aug 2026

Synergistic 2D MoO₃/g-C₃N₄ heterostructures for highly efficient photocatalytic removal of cationic dyes: a response surface methodology approach

2D MoO₃/g-C₃N₄ nanosheets were synthesized via a simple impregnation–hydrothermal approach and investigated as efficient photocatalysts for the degradation of cationic dyes in water. Structural and compositional analyses confirmed the successful formation of a tightly coupled heterostructure. Density functional theor...

M. F. Hussein, Nada Alhathlaul, K. Alshammari et al. · Arabian Journal of Chemistry · 0 citations

Open access Aug 2026

Design and Synthesis of Novel Morpholine-Derived Nitrogen-Rich Scaffolds as Multifunctional Anticancer and Antibacterial Agents: Biological Evaluation and Computational Studies

The combined biochemical, cellular, and computational findings support the proposed involvement of the EGFR/PI3K/mTOR signaling pathway in its antiproliferative activity and identify DNA gyrase as a potential antibacterial target.

Hagar S. El-Hema, Esraa M. Adel, W. El-Dougdoug et al. · Pharmaceutics · 0 citations