Author

M.-F. Yuen

2 papers indexed here

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Review Open access Oct 2026

Clinical Prospect of Novel Therapies for Functional Cure in Chronic Hepatitis B.

RNA-targeting therapies and combination regimens offer promising approaches in attaining functional cure in CHB, with bepirovirsen (an unconjugated antisense oligonucleotide) standing out as the only agent completed in Phase III study showing efficacious results.

K. Ho, R. Hui, L. Mak et al. · Journal of Gastroenterology... · 0 citations

Open access Oct 2026

Profile and Predictors of Hepatitis B Surface Antigen Seroreversion Following PEG-IFNα with or Without Therapeutic Vaccine BRII-179 or siRNA Elebsiran: A Post Hoc Pooled Analysis of Two Randomized Controlled Trials in Patients with Chronic Hepatitis B Virus Infection

Background/Objectives: The clinical implications of HBsAg seroreversion following HBV functional cure therapies remain unclear. In two randomized phase 2 trials, therapeutic vaccine BRII-179 or siRNA elebsiran in combination with PEG-IFNα was evaluated versus PEG-IFNα monotherapy. This pooled analysis characterized the...

Zhi-Liang Gao, Bing-Liang Lin, G. Wong et al. · Vaccines · 0 citations