Author

M. Fawzy

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Meta-analysis Open access Sep 2026

Telmisartan-based monotherapy and combination regimens for blood pressure control in adults with hypertension: a systematic review, meta-analysis, and GRADE assessment

To evaluate the efficacy, safety, and certainty of evidence for telmisartan-based antihypertensive regimens in adults with hypertension. This systematic review and meta-analysis followed PRISMA 2020. PubMed/MEDLINE, Scopus, Web of Science, and Cochrane CENTRAL were searched from inception to 2026. Eligible studies enro...

B. A. Alsel, Muzun Saleh Alturqi Alanazi, Aryam Salem Mgairan Alrawaili et al. · BMC Cardiovascular Disorders · 0 citations

Open access Aug 2026

Liposomal Honokiol Nanoparticles Attenuate Manganese-Induced Hippocampal Neurotoxicity via NRF2/HO-1 and SIRT1/PGC-1α Pathways: Association with Oxidative Stress, Neuroinflammation, Mitochondrial Dysfunction, and Apoptosis

Background/Objectives: Manganese (Mn) is a neurotoxic trace element whose excessive accumulation in the brain can induce hippocampal damage via oxidative stress, mitochondrial dysfunction, neuroinflammation, and apoptosis. This study investigated whether honokiol (HNK) and its liposomal nanoformulation (HNK-LNPs) can a...

Raed AlRuwaili, E. Elmorsy, M. Abdel-Daim et al. · Brain Science · 0 citations

Open access Sep 2026

Liposomal Morin Attenuates DMH-Associated Colonic Oxidative Stress, Inflammation, and Apoptosis/Autophagy-Related Dysregulation in Rats

Background/Objectives: Oxidative stress, chronic inflammation, disrupted apoptosis, and altered autophagy are biological processes implicated in colorectal tumor development. Morin is a plant-derived flavonoid with antioxidant and anti-inflammatory properties, but its limited solubility and bioavailability may limit it...

Mohammed A. Akeel, E. Elmorsy, F. Alshammari et al. · Pharmaceuticals · 0 citations

Open access Aug 2026

Hesperetin-Loaded PLGA Nanoparticles Ameliorate Cisplatin-Induced Oxidative Stress and Testicular Dysfunction in Rats: Association with NRF2/HO-1, NF-κB, and ACSL4/GPX4/SLC7A11 Signaling Modulation

HES and HES-PLGA-NPs were associated with multi-mechanistic protection against cisplatin-induced oxidative, inflammatory, apoptotic, and ferroptosis-associated damage in the testes, and may represent a promising nanoantioxidant candidate warranting further investigation for preserving male reproductive function during...

Mohammed A. Akeel, E. Elmorsy, Aly A. M. Shaalan et al. · Antioxidants · 0 citations