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Open access Jan 2026

Targeting lncRNA PVT1/miR‐145‐5p/ABCC‐1 Pathway Enhances Paclitaxel Sensitivity and Suppresses Melanoma Progression

Background As a highly aggressive type of skin cancer, melanoma cells show significant resistance against a variety of chemotherapeutics, such as paclitaxel, which limits the efficacy of the treatment. Studies have highlighted the potential role of noncoding RNA dysregulation in melanoma, affecting tumor progression an...

Negar Pedram, R. Safaralizadeh, M. Feizi et al. · 0 citations
Jul 2026

Involvement of the cannabinoid receptors of the basolateral amygdala in the orexin A-mediated modulation of the stress-induced analgesia.

Induction of innate fear decreased flinch frequency only during the first phase of the formalin test, and intra-BLA administration of orexin-A may retrogradely affect Cb1R-containing interneurons and increase Cb1R expression, thereby counteracting stress-induced analgesia.

Mahnaz Aghaei, R. Khakpay, Fatemeh Khakpai et al. · 0 citations

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