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Author

M. Felices

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Jul 2026

Leveraging modular TriKE-PACC molecules capable of dual-antigen targeting to enhance NK-cell immunotherapy in AML 2257266

The engineered TriKEs with Poly Antigen Cytokine Complexes (TriKE-PACCs), which combine dual AML-specific targeting with NK activation and persistence, enhance NK cell proliferation and antitumor activity compared to TriKEs or IL-15 therapies alone.

Anders W. Matson, Caden Caligiuri, Katherine M. Koehler et al. · 0 citations
Jul 2026

Abstract A021: Enhancing NK cell immunotherapy in non-small cell lung cancer using dual-antigen targeting Tri-Specific Killer Engagers (TriKEs/TriKE PACCs)

Treatment with TriKE-PACCs significantly enhanced NK cell degranulation, cytokine production, and tumor killing compared to single-antigen TriKEs and IL-15 alone, particularly in heterogeneous antigen settings.

Rachel N. Steinmetz, S. Phung, Joshua T. Walker et al. · 0 citations

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