Review
Open access
Sep 2026
Conformational dynamics of fuzzy interfaces in disordered protein complexes: mapping key residues and binding modes beyond NMR models
Understanding the dynamic behavior of fuzzy complexes formed by intrinsically disordered proteins (IDPs) is challenging due to their conformational flexibility. Nuclear Magnetic Resonance (NMR) structural bundles satisfy experimental constraints and inherently provide an overview of alternative conformations in solutio...
M. Fernández, María Clara Bastien, Franco G. Tavolaro et al.
· Frontiers in Bioinformatics · 0 citations