Author

M. Fernández‐Bermejo

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Open access Sep 2026

Zileuton protects pancreatic stellate cells from oxidative stress and ferroptosis by modulating the Nrf2 pathway and mitochondrial activity

Lipoxygenases exhibit a leading role in cancer development and growth. Additionally, pancreatic stellate cells (PSCs) are pivotal in the formation of fibrotic tissue in pancreatic tumors. In this work, we have studied the effects of the 5-lipoxygenase (5-LOX) inhibitor, zileuton, on rat PSCs. Cell viability was analyze...

M. Estarás, Cándido Ortiz-Placín, S. Martínez-Morcillo et al. · Journal of physiology and bi... · 0 citations

Open access Aug 2026

Stress granules confer an early vulnerability in KRAS-driven pancreatic tumorigenesis.

Pancreatic ductal adenocarcinoma (PDAC) is initiated by activating KRAS mutations, yet most pancreatic cells fail to survive the induced oncogenic stress. How a subset adapts to and initiates malignant transformation remains unclear. Here, we show that stress granules (SGs) formation is a key adaptive mechanism enablin...

Matías Estarás, Emma Cosialls, Gareth Pollin et al. · Cell Reports · 0 citations