M. Fishel

Mechanism and clinical relevance of metabolic-immune cross-talk in pancreatic tumor microenvironment.

Metabolic stress-induced immunosuppression begins as early as the precancerous stage in pancreatic ductal adenocarcinoma (PDAC), increases with disease progression, and is characterized by the abundant suppressive myeloid and lymphoid cells. Metabolic adaptation and reprogramming are critical for the survival and funct...