Aug 2026
The Biosynthetic Pathway for the Hybrid NRPS-NIS Siderophore Nocardichelin Contains NcdG, a Succinylase that Cleaves the Hydroxamate Bond of the Acylcadaverine Intermediate
It is demonstrated that NcdG cleaves the hydroxamate bond of HSC and HSC dimers and also determine the structure of NcdG, an acyl hydroxamate-cleaving Ntn hydrolase that may help to modulate levels of the two building blocks, HSC and HRC.
M. Fisk, Collin E. Merrick, T. Wencewicz et al.
· ACS Chemical Biology · 0 citations