How native metal-binding sites accommodate uranyl: a comparative study of human serum transferrin, human serum albumin, and an engineered uranyl-binding protein.
Understanding how the uranyl ion (UO22+) exploits native metal-binding sites in human proteins is essential for elucidating uranium transport, accumulation, and toxicity. In this computational study, we investigated how uranyl is accommodated within the protein pockets of human serum transferrin and human serum albumin...