Aging-associated loss of chromatin compaction is linked to derepression of retrotransposable elements (RTEs) in mouse and human tissues. Whether such RTE transcription contributes to the microglia activation that is common in aged brains is unknown. Here, we show that DAXX, a histone chaperone and RTE repressor, is dow...
Xin Yan, Christina Georgopoulou, Hang-Mao Lee et al.· Nature Neuroscience· 0 citations
ZenReg, an open-source Python platform that formulates common 2D+t, 3D, and 3D+t microscopy registration tasks as modular, geometry-preserving alignment problems, turns motion correction into an inspectable, memory-aware, and FAIR-oriented component of reproducible bioimage analysis.
By separating reusable analysis logic from project-specific configuration, CellColoc offers an extensible foundation for community-driven microscopy workflows that need transparent per-cell overlap classification, morphology readouts, and reusable batch analysis.
F. Musacchio, Henrike Antony, Arush Baijal et al.· bioRxiv· 1 citation
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